https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30189 Hfe−/−xTfr2mut mouse model. This was accompanied by altered expression of a group of myelin-related genes, including a suite of genes causatively linked to the rare disease family ‘neurodegeneration with brain iron accumulation’ (NBIA). Expanded data mining and ontological analyses have now identified additional myelin-related transcriptome changes in response to brain iron loading. Concordance between the mouse transcriptome changes and human myelin-related gene expression networks in normal and NBIA basal ganglia testifies to potential clinical relevance. These analyses implicate, among others, genes linked to various rare central hypomyelinating leukodystrophies and peripheral neuropathies including Pelizaeus-Merzbacher-like disease and Charcot-Marie-Tooth disease as well as genes linked to other rare neurological diseases such as Niemann-Pick disease. The findings may help understand interrelationships of iron and myelin in more common conditions such as hemochromatosis, multiple sclerosis and various psychiatric disorders.]]> Wed 11 Apr 2018 16:58:00 AEST ]]> A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9503 Wed 11 Apr 2018 13:47:54 AEST ]]> Blocked, delayed, or obstructed: what causes poor white matter development in intrauterine growth restricted infants? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31317 Wed 10 Nov 2021 15:05:04 AEDT ]]> Differential expression of the GABA transporters GAT-1 and GAT-3 in brains of rats, cats, monkeys and humans https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:479 Thu 25 Jul 2013 09:09:52 AEST ]]> Effect of postnatal progesterone therapy following preterm birth on neurosteroid concentrations and cerebellar myelination in guinea pigs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28160 Sat 24 Mar 2018 07:36:34 AEDT ]]> Examining Neurosteroid-Analogue Therapy in the Preterm Neonate For Promoting Hippocampal Neurodevelopment https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50958 Mon 14 Aug 2023 15:11:28 AEST ]]> Neurosteroid-based intervention using Ganaxolone and Emapunil for improving stress-induced myelination deficits and neurobehavioural disorders https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47891 Mon 06 Feb 2023 12:21:53 AEDT ]]> Corticosterone administration alters white matter tract structure and reduces gliosis in the sub-acute phase of experimental stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40655 Fri 22 Jul 2022 14:02:02 AEST ]]> Prenatal stress induces translational disruption associated with myelination deficits https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53108 Fri 17 Nov 2023 11:28:01 AEDT ]]> Impaired Oligodendrocyte Development Following Preterm Birth: Promoting GABAergic Action to Improve Outcomes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49419 Fri 12 May 2023 15:02:32 AEST ]]> Dual isolation of primary neurons and oligodendrocytes from guinea pig frontal cortex https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54665 Fri 08 Mar 2024 10:57:23 AEDT ]]>